Western New York's Beef on Weck is a roast beef sandwich on a kummelweck bread with horseradish and jus.
Torta de adobada (spicy pork), milanesa (cutlet), or huevo (eggs) on a soft roll is what Los Angeles taco stand fans order when they're truly hungry.
A southern staple, hasn't caught on in the north. A simple hot sandwich with wonderful pimento cheese between two slices of buttered Texas bread beats all other grilled cheeses.
New Orleans' Central Grocery is credited with creating the Muffaletta sandwich, and we owe them a Wookiee life debt. Italian sliced meats and cheeses, briny olive salad.
Kentucky's Hot Brown is more like eggs Benedict than any of the other sandwiches on this list, but leaving this exquisite marriage of turkey, bacon, and Mornay sauce off would be heresy.
Po'Boy Louisiana makes their second appearance on this list with their Po' boy, which is the perfect way to consume fried catfish or shrimp on a crusty French baguette
Before you reply "well actually," the Cuban sandwich was invented in Florida—Ybor City, Tampa, or Key West, depending on who you ask.
Philippe or Cole invented the French Dip in Los Angeles. Both are great, however Philippe's French Dip comes slathered in au jus, while Cole's is served on the side for dipping.
Whether the Reuben originated in New York City or Omaha, Nebraska, corned beef, sauerkraut, Swiss, and Russian dressing on rye is amazing.